General Research
Model: rat
Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury
Simplified Version Available
How Hydrogen Gas May Protect Against Spinal Cord Injury
A study from Japan found that inhaling hydrogen gas can help protect against spinal cord ischemia-reperfusion injury. The gas has antioxidant properties that reduce damage to the spinal cord. This discovery could lead to new treatments for spinal cord injuries and other conditions, such as heart health during surgery and lung disease treatment.
Read Simplified ArticleAbstract
Publish Year 2021 Country Japan Rank Positive Journal Journal of Thoracic and Cardiovascular Surgery Primary Topic Spine Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: The increase in extracellular glutamate induced by spinal ischemia was significantly suppressed by 3% hydrogen gas inhalation (P < .05). This effect was produced in increasing order: 1%, 2%, and 3%. Conversely, the preadministration of glutamate transporter-1 inhibitor diminished the suppression of spinal ischemia-induced glutamate increase observed during the inhalation of 3% hydrogen gas. Immunofluorescence indicated the expression of glutamate transporter-1 in the spinal ischemia group was significantly decreased compared with the sham group, which was attenuated by 3% hydrogen gas inhalation (P < .05). Conclusions: Our study demonstrated hydrogen gas inhalation exhibits a protective and concentration-dependent effect against spinal ischemic injury, and glutamate transporter-1 has an important role in the protective effects against spinal cord injury.