General Research
Model: rat
Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging
Simplified Version Available
Hydrogen-Rich Water: A Potential Shield Against Kidney Damage
A Japanese study found that hydrogen-rich water may protect kidneys from damage caused by certain antibiotics. The water reduces oxidative stress, acting like a fire extinguisher in our cells. This could be a simple way to safeguard kidney health, especially for those taking strong medicines.
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Publish Year 2011 Country Japan Rank Positive Journal Magnetic Resonance in Medical Sciences Primary Topic Kidney Secondary TopicAcute Kidney Injury Model Rat Tertiary TopicAntibiotic Toxicity (Gentamicin) Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement
Purpose
Materials and methods: We acquired T(2)*-weighted images (T(2)*WI) of 21 rats on Days 0, 2, 4, and 7 using a 1.5-tesla MR imaging system. The rats were divided into 3 groups of seven each: control rats had free access to standard water and no gentamicin (GM) injection; rats designated the GM group had free access to standard water and were injected with GM (80 mg/kg/day) subcutaneously for 7 days; and the third group, designated the GM+HW group, had free access to HW and were injected with GM. R(2)* (=1/T(2)*) was estimated from T(2)*WI.