General Research
Model: rat
Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap
Simplified Version Available
Healing Skin from the Inside Out: The Power of Hydrogen-Rich Saline
A study on rat skin flaps found that hydrogen-rich saline can reduce damage from ischemia/reperfusion injury, promoting skin healing and reducing scarring. Hydrogen water, made at home using water ionizers or hydrogen generators, may also promote healthier skin. The study's findings open up new possibilities for the use of hydrogen-rich saline in skin healing.
Read Simplified ArticleAbstract
Publish Year 2013 Country China Rank Positive Journal Journal of Zhejiang University - Science B Primary Topic Skin Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicPlastic Surgery Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.