General Research
Model: rat
Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction
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How Hydrogen Water May Help Prevent Bladder Problems
Hydrogen water may help prevent bladder problems like detrusor overactivity, according to a study on rats. The antioxidant properties of hydrogen water could reduce oxidative stress and protect the bladder from damage. While more research is needed, the results are promising for people prone to bladder issues.
Read Simplified ArticleAbstract
Publish Year 2016 Country Japan Rank Positive Journal Journal of Urology Primary Topic Bladder Secondary TopicBladder Outlet Obstruction Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement
Purpose
Materials and methods: H2-water was made by dissolving H2 gas in ordinary drinking water (OW) using a hydrogen water-producing apparatus. The BOO model was surgically induced in male rats. Rats with BOO were fed with H2-water or OW. On week 4 after surgery, cystometry was performed. Oxidative stress markers and bladder nerve growth factor (NGF) level were determined. Bladder tissues were processed for pharmacological studies and for histological analysis.