General Research
Model: in_vitro
Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil
Simplified Version Available
How Hydrogen-Rich Saline May Protect Against Hearing Loss
Researchers in Japan found that hydrogen-rich saline can help prevent ischemia-induced hearing loss in gerbils. The study's findings have significant implications for humans and offer new hope for those affected by hearing loss. Hydrogen water can be made at home using water ionizers or hydrogen generators.
Read Simplified ArticleAbstract
Publish Year 2017 Country Japan Rank Positive Journal Neuroscience Letters Primary Topic Ear Secondary TopicHearing Loss Model Gerbil Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: In non-ischemia animals, ABR thresholds and histological findings of the cochlea did not change by administration of saline or hydrogen-rich saline. In contrast, transient cochlear ischemia caused a 24.2±3.8dB increase in the ABR threshold at 8kHz, and a decrease of 14.1%±1.8% in the number of inner hair cells (IHCs) at the basal turn on day 7. Ischemic damage was more severe at 16 and 32kHz. When the animals were treated with hydrogen-rich saline, cochlear damage was significantly reduced: the increase in ABR threshold was 11.7±2.6dB at 8kHz and the IHC loss was 7.5%±2.1% at the basal turn on day 7. The effects of hydrogen-rich saline were more prominent at higher frequencies. Conclusions: Intravenous administration of hydrogen-rich saline was effective in preventing acute hearing loss due to transient cochlear ischemia.