General Research
Model: rat
Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study
Simplified Version Available
How Hydrogen Gas Can Help Save Lives in Liver Transplants
A study from Japan found that hydrogen gas can help reduce damage to liver transplants by reducing inflammation and oxidative stress. This could lead to better outcomes for people who need liver transplants. The research is a promising step forward in improving liver transplant surgery.
Read Simplified ArticleAbstract
Publish Year 2018 Country Japan Rank Positive Journal Surgery Today Primary Topic Liver Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicTransplantation/Graft Injury Vehicle Water (Dissolved) pH Neutral Application Immersion Comparison Complement
Methods
Results: In the NT group, liver enzyme leakage, apoptosis, necrosis, energy depletion, redox status, impaired microcirculation, and bile production were indicative of severe IRI, whereas in the H2 group these impairments were significantly suppressed. The phosphorylation of cytoplasmic MKK4 and JNK were enhanced in the NT group and suppressed in the H2 group. NFkB-p65 and c-Fos in the nucleus were unexpectedly unchanged by IRI regardless of H2 treatment, indicating the absence of inflammation in this model.
Results
Conclusion: H2 was observed to ameliorate IRI in the DCD liver by maintaining microcirculation, mitochondrial functions, and redox status, as well as suppressing the cytoplasmic MKK4-JNK-mediated cellular death pathway.