General Research
Model: mouse
Oral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis
Simplified Version Available
Can Hydrogen-Rich Water Help Protect Your Kidneys from Damage?
A 2021 study found that drinking hydrogen-rich water may help protect kidneys from damage caused by oxalate. The study used a mouse model and found reduced oxidative stress, inflammation, and fibrosis in mice who drank hydrogen-rich water. While more research is needed, the findings are promising for human health and kidney protection.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Frontiers in Medicine Primary Topic Kidney Secondary TopicKidney Stones Model Mouse Tertiary TopicOxalate Injury Vehicle Water (Electrolysis) pH Neutral Application Ingestion Comparison Complement
Methods
Results: Crystal deposition, tubular injury, fibrosis and increased ROS production in kidneys of mice induced by oxalate diet were improved with HRW administration. The indexes of renal injury, inflammation and oxidative stress in serum of mice were upregulated by oxalate diet, which were reduced by HRW. A total of 3,566 differential genes were screened by RNA-seq and these genes were analyzed by pathway enrichment and PI3K/AKT, NF-κB, and TGF-β pathways were selected for further verification. The expressions of molecules related to PI3K-AKT pathway (PI3K, AKT, and p-AKT), NF-κB pathway (NF-κB p65, p- NF-κB p65, NLRP3, and IL-1β) and TGF-β pathway (TGF-β, TGF-βRI, TGF-βRII, p-Smad2, and p-Smad3) in renal tissues were increased by oxalate diet, which were reduced by HRW administration.
Results
Conclusion: HRW may alleviate oxalate-induced kidney injury with its anti-oxidative, anti-inflammatory and anti-fibrotic effects via inhibiting PI3K/AKT, NF-κB, and TGF-β pathways.