General Research
Model: pig
Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss
Simplified Version Available
How Hydrogen-Saturated Saline Fights Noise-Induced Hearing Loss
Noise-induced hearing loss is a growing concern, but research suggests hydrogen-saturated saline could be a solution. A 2017 study found that guinea pigs injected with the solution had less hearing damage after exposure to loud noises. This breakthrough could lead to new treatments for hearing loss and other conditions.
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Publish Year 2017 Country China Rank Positive Journal Acta Oto-Laryngologica Primary Topic Ear Secondary TopicHearing Loss Model Guinea Pig Tertiary TopicNoise Pollution Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: The results showed that pre-treatment with hydrogen-saturated saline could significantly attenuate noise-induced hearing loss. The concentration of 8-HOdG was also significantly decreased in the hydrogen-saturated saline group compared with the normal saline group. After noise exposure, the concentrations of IL-1, IL-6, TNF-α, and ICAM-1 in the cochlea of guinea pigs in the hydrogen-saturated saline group were dramatically reduced compared to those in the normal saline group. The concentrations of HMGB-1 and IL-10 in the hydrogen-saturated saline group were significantly higher than in those in the normal saline group immediately and at 7 d after noise exposure. Conclusions: This study revealed for the first time the protective effects of hydrogen-saturated saline on noise-induced hearing loss (NIHL) are related to both the anti-oxidative activity and anti-inflammatory activity.