General Research
Model: rat
Molecular Hydrogen Suppresses Renal Injury in Chronic Kidney Disease Rats
Simplified Version Available
How Hydrogen Water May Help Protect Your Kidneys
A study found that hydrogen water may help protect the kidneys from damage. Researchers gave rats with chronic kidney disease hydrogen water to drink and saw promising results. This could be good news for people at risk for kidney disease, but more research is needed.
Read Simplified ArticleAbstract
Publish Year 2018 Country China Rank Positive Journal Journal of Bioprocessing and Biotechniques Primary Topic Kidney Secondary TopicChronic Kidney Disease Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Water, Commercial (Brand Unknown) pH Neutral Application Ingestion Comparison Complement
Background
Methods: Twenty Dahl S rats were given HW and tap water (TW), over a 4-week period. Thereafter, they were allocated to either group; non stressed (NS), and oxi-carbonyl stressed (OC: 5% salt diet and 1% methylglyoxal in drinking water) group, respectively (HW, TW n=5 each group). OS groups were subjected to unilateral kidney ischemic reperfusion (IR) in the final week.
Methods
Results: No differences were found in blood pressure and urinary parameters between HW and TW. Glomerular adhesion rates in the IR kidney and positive osteopontin of the non-IR kidney were significantly higher in OC rats on HW, respectively. ED-1 staining on HW was significantly lower than TW in both the IR and non-IR kidneys of the OC rats. Plasma MCP-1 was significantly lower on HW after IR.
Results
Conclusion: Drinking HW at least partly suppressed renal damage in rats with combination of oxidative, carbonyl and ischemic stimulus.