General Research
Model: rat
Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats
Simplified Version Available
Healing Spinal Cord Injuries with Hydrogen: A Breakthrough Study
A 2014 study found that molecular hydrogen can suppress reactive astrogliosis and reduce oxidative stress in rats with spinal cord injuries. This breakthrough could lead to new treatments for spinal cord injuries, offering hope for a better quality of life. Molecular hydrogen has already shown potential in treating other conditions related to oxidative stress.
Read Simplified ArticleAbstract
Publish Year 2014 Country China Rank Positive Journal CNS Neuroscience and Therapeutics Primary Topic Spine Secondary TopicSpinal Cord Injury Model Rat Tertiary TopicOxidative Stress Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: In the HS group, the expression of STAT3, p-STAT3, and GFAP and the proinflammatory cytokines were decreased in local spinal cord on postoperation day (POD) 3; on PODs 7 and 14, reactive astrogliosis was suppressed, and the locomotor function was also improved. Furthermore, hydrogen-rich medium attenuated the intracellular production of ROS (especially HO•), astrogliosis, and the secretion of proinflammatory cytokines in astrocytes 12 h after H2O2-induced injury. Conclusions: Molecular hydrogen could suppress reactive astrogliosis after contusive SCI and reduce the release of proinflammatory cytokines produced by active astrocytes related to oxidative injury. Thus, molecular hydrogen is potential to be a neuroprotective agent.