General Research
Model: human
Inhaling Hydrogen Ameliorates Early Postresuscitation EEG Characteristics in an Asphyxial Cardiac Arrest Rat Model
Simplified Version Available
How Inhaling Hydrogen Can Help After Cardiac Arrest
Inhaling hydrogen gas may help reduce brain damage after cardiac arrest, according to a recent study. Scientists found that rats who inhaled hydrogen after cardiac arrest had better brain function and fewer signs of damage. This promising research could lead to new treatments for cardiac arrest patients.
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Publish Year 2019 Country China Rank Positive Journal BioMed Research International Primary Topic Brain Secondary TopicCardiopulmonary Resuscitation (CPR) Model Rat Tertiary TopicHypoxia-Ischemia Vehicle Gas pH N/A Application Inhalation Comparison Complement
Background
Methods: Cardiopulmonary resuscitation was initiated after 5 min of untreated CA in 40 adult female Sprague-Dawley rats. Animals were randomized for ventilation with 98% oxygen plus 2% hydrogen (H2) or 98% oxygen plus 2% nitrogen (Ctrl) under normothermia for 1 h. EEG characteristics were continuously recorded for 4 h, and the relationships between quantitative EEG characteristics and 96 h neurological outcomes were investigated.
Methods
Results: No differences in baseline and resuscitation data were observed between groups, but the survival rate was significantly higher in the H2 group than in the Ctrl group (90% vs. 40%, P < 0.01). Compared to the Ctrl group, the H2 group showed a shorter burst onset time (21.85 [20.00-23.38] vs. 25.70 [22.48-30.05], P < 0.01) and time to normal trace (169.83 [161.63-208.55] vs. 208.39 [186.29-248.80], P < 0.01). Additionally, the burst suppression ratio (0.66 ± 0.09 vs. 0.52 ± 0.17, P < 0.01) and weighted-permutation entropy (0.47 ± 0.16 vs. 0.34 ± 0.13, P < 0.01) were markedly higher in the H2 group. The areas under the receiver operating characteristic curves for the 4 EEG characteristics in predicting survival were 0.82, 0.84, 0.88, and 0.83, respectively. Conclusions: In this asphyxial CA rat model, the improved postresuscitation EEG characteristics for animals treated with hydrogen are correlated with the better 96 h neurological outcome and predicted survival.