General Research
Model: mouse
Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages
Simplified Version Available
Healing the Spine: How Hydrogen Inhalation Helps Spinal Cord Injuries
A recent study found that inhaling hydrogen gas can help treat spinal cord injuries in mice by protecting neurons and reducing oxidative stress. This non-invasive treatment has the potential to be used in hospitals or at home and may also be effective for other conditions. While more research is needed, the results are promising and offer hope for better treatments.
Read Simplified ArticleAbstract
Publish Year 2018 Country China Rank Positive Journal Cellular Physiology and Biochemistry Primary Topic Spine Secondary TopicSpinal Cord Injury Model Mouse Tertiary TopicOxidative Stress Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. ROS generation, oxidative stress injury-related markers, and the number of apoptotic neurons were significantly reduced after hydrogen treatment. The ATP production and mPTP function in injured neurons were preserved by hydrogen incubation. The expression levels of Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were inhibited by hydrogen treatment. BMS scores and the footprint assessment of mice with SCI were improved by hydrogen inhalation. Conclusions: Hydrogen inhalation (75%) ameliorated SCI in vivo and attenuated neuronal mechanical injuries in vitro, and its protective effect on spinal cord neurons was exerted in a dose-dependent manner. The underlying mechanisms included reducing ROS generation and oxidative stress, inhibiting neuronal apoptosis, and restoring mitochondrial construction and function. Cox8b, Cox6a2, Cox7a1, Hspb7, and Atp2a1 were identified as potential target genes of hydrogen treatment.