General Research
Model: mouse
Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway
Simplified Version Available
How Hydrogen Inhalation Can Help Protect Your Liver During Surgery
A study found that inhaling high concentrations of hydrogen can help protect the liver from damage during surgery. Hydrogen has antioxidant properties that can reduce damage caused by free radicals. This research could lead to new ways to protect the liver during surgery, improving outcomes for patients.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Biochemical Pharmacology Primary Topic Liver Secondary TopicSurgery/Transplantation Model Mouse Tertiary TopicIschemia-Reperfusion Injury Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Liver dysfunction, hepatic pathological injury, infiltration of inflammatory cytokines, and hepatocyte apoptosis were observed after hepatic I/R, accompanied by inhibition of the PI3K-Akt pathway. HCH significantly improved liver function, reduced serum inflammatory cytokines, and inhibited hepatocyte apoptosis, and also induced the PI3K-Akt pathway activation. In the presence of LY294002 or ZM241385, the protective effects of HCH were markedly attenuated, but the effects of ZM241385 were reversed by bpv(HOpic).
Results
Conclusion: Our findings indicate that HCH may protect the liver against I/R injury through the A2A dependent PI3K-Akt pathway.