General Research
Model: pig
Influence of Hydrogen-rich Saline on Hepatocyte Autophagy During Laparoscopic Liver Ischaemia-reperfusion Combined Resection Injury in Miniature Pigs
Simplified Version Available
How Hydrogen-Rich Saline Helps Protect Your Liver During Surgery
Researchers in China have found that hydrogen-rich saline can help protect liver cells during surgery. This liquid, which contains dissolved hydrogen gas, helps cells get rid of damaged or dysfunctional parts. The study's findings could lead to better outcomes for people undergoing liver surgery.
Read Simplified ArticleAbstract
Publish Year 2018 Country China Rank Positive Journal Journal of Veterinary Research Primary Topic Liver Secondary TopicSurgery/Transplantation Model Pig Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Compared with the sham group, the level of autophagy of hepatocytes increased in the IRI and IRI + HRS groups, corresponding to high oxidative stress and severe liver function injury. Liver function, antioxidant content, autophagy levels, and liver injury were improved after intervention with HRS in the IRI + HRS group compared with the IRI group.
Results
Conclusion: Intervention with hydrogen-rich saline could exert a protective effect against liver ischaemia-reperfusion combined resection injury through the reduction of oxidative stress and hepatocyte autophagy.