General Research
Model: rat
Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury
Simplified Version Available
How Hydrogen-Rich Saline Can Help Protect Lungs During Surgery
A study found that immersing lungs in hydrogen-rich saline can help reduce damage during surgery. The antioxidant properties of hydrogen help to neutralize free radicals and protect the lungs. This breakthrough could lead to better outcomes for patients undergoing lung surgery.
Read Simplified ArticleAbstract
Publish Year 2017 Country Japan Rank Positive Journal European Journal of Cardio-Thoracic Surgery Primary Topic Lung Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Immersion Comparison Complement
Methods
Results: Immersing lungs in hydrogen-rich saline resulted in an elevated hydrogen concentration in the lung (6.9 ± 2.9 μmol/1 g lung). After IRI, pulmonary function (pulmonary compliance and oxygenation levels) was significantly higher in the hydrogen-rich saline group than in the normal saline group ( P < 0.05). Similarly, pro-inflammatory cytokine levels (interleukin-1β and interleukin-6) in the left lung were significantly lower in the hydrogen-rich saline group than in the normal saline group ( P < 0.05). Conclusions: Immersing lungs in hydrogen-rich saline delivered hydrogen into the lung and consequently attenuated lung IRI. Hydrogen-rich solution appears to be a promising approach to managing lung IRI.