General Research
Model: rat
Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury
Simplified Version Available
How Hydrogen Therapy May Help Protect Your Liver During Shock
A recent study found that a hyperoxygenated hydrogen-rich solution can help suppress liver injury caused by shock and resuscitation. Hydrogen therapy reduces oxidative stress, which contributes to liver damage. This treatment may offer a new way to protect the liver and promote healing, and could be used in combination with other treatments.
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Publish Year 2017 Country China Rank Positive Journal Journal of Surgical Research Primary Topic Liver Secondary TopicShock Model Rat Tertiary TopicHemorrhagic Shock Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Oxygen
Background
Materials and methods: Rats (n = 60) were randomly divided into 5 groups (n = 6 per group at each time point). One group underwent sham operation, and the others were subjected to severe hemorrhagic shock and then treated with lactated Ringer's solution (LRS), hydrogen-rich solution, hyperoxygenated solution, or HHOS. At 2 and 6 h after resuscitation, blood samples (n = 6) were collected from the femoral artery and serum concentrations of alanine aminotransferase and aspartate aminotransferase (AST) were measured. Rats were then sacrificed, and histopathological changes in the liver were evaluated by quantifying the percentage of apoptotic cells by caspase-3 immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick-end labeling. Inflammation was assessed by assessing malondialdehyde content and tumor necrosis factor-α, and interleukin (IL)-6 expression.