General Research
Model: rat
Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats
Simplified Version Available
How Hydrogen-Rich Solutions Can Help Protect Lungs from Shock-Related Damage
A recent study found that a hydrogen-rich solution can help protect lungs from damage caused by hemorrhagic shock. The solution, which is rich in hydrogen and oxygen, was shown to reduce lung injury in rats. This research could have important implications for the treatment of lung injuries and may even lead to new treatments for other conditions that affect the lungs. Further research is needed to fully understand the benefits of hydrogen-rich solutions, but the results are promising.
Read Simplified ArticleAbstract
Publish Year 2019 Country China Rank Positive Journal Journal of Surgical Research Primary Topic Lung Secondary TopicShock Model Rat Tertiary TopicHemorrhagic Shock Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Oxygen
Background
Materials and methods: SD rats were randomly divided into five groups (n = 6 at each time point in each group) and were exposed to Hemorrhagic shock induced ALI, and then treated with lactated Ringer's solution (LRS), hyperoxygenated solution, HS, and HOHS, respectively. The protective effects of these solutions were assessed using methods as follows: arterial blood samples were collected for blood gas analysis; Bronchoalveolar lavage fluid was collected for cell count and protein quantification; lung tissue samples were collected to measure wet/dry ratio, as well as levels of T-SOD, MDA, TNF-α, and IL-6; Caspase-3 and TUNEL-positive cells, and pathological changes were observed under light microscope; ALI was scored using the Smith scoring method; ultrastructural changes of lung tissues were further observed with transmission electron microscopy.