General Research
Model: rat
Hyperbaric oxygen combined with hydrogen-rich saline protects against acute lung injury
Simplified Version Available
How Hydrogen-Rich Saline and Hyperbaric Oxygen Can Protect Your Lungs
A recent study found that combining hyperbaric oxygen with hydrogen-rich saline can protect against acute lung injury. This breakthrough has promising implications for people at risk of lung damage. The study used rats to test the effects of this combination therapy and found it to be more effective than using either treatment alone.
Read Simplified ArticleAbstract
Publish Year 2023 Country China Rank Positive Journal Undersea & Hyperbaric Medicine Primary Topic Lung Secondary TopicLung Injury Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Hyperbaric Oxygen
Background
Results: In the groups treated with HBO2 + HRS, pulmonary pathological data, wet-dry weight ratio, and inflammatory factors of pulmonary tissues and alveolar lavage fluid were significantly superior to those of the sham group (p≺0.05). Cell apoptosis detection revealed that no single agent treatment of HRS or HBO2, or combination treatment, could alleviate all cell apoptosis. HRS combined with HBO2 treatment was superior to single treatment (p≺0.05).
Results
Conclusion: HRS or HBO2 single treatment could decrease inflammatory cytokines release in lung tissue, reduce the accumulation of oxidative products and alleviate apoptosis of pulmonary cells, then lead to positive therapeutic effects on ALI induced by LPS. Furthermore, HBO2 combined with HRS treatment presented a synergy effect on cell apoptosis decrease and a decline in inflammatory cytokine release and related inflammatory product generation, compared with a single treatment.