General Research
Model: rat
Hydrogen water alleviates lung injury induced by one-lung ventilation
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How Hydrogen Water May Help Reduce Lung Damage During Surgery
A 2015 study found that hydrogen water may help reduce lung damage caused by one-lung ventilation during surgery. The study on rats showed promising results, with those drinking hydrogen water experiencing less lung damage than those drinking regular water. This could have implications for human patients undergoing lung surgery, potentially leading to faster recovery times and fewer complications.
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Publish Year 2015 Country China Rank Positive Journal Journal of Surgical Research Primary Topic Lung Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicVentilator-Induced Lung Injury Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement
Background
Materials and methods: Male Sprague-Dawley rats (n = 32, 240-260 g) were divided randomly into the following four groups: sham group, sham + H2 group, OLV group, OLV + H2 group. The rats drank hydrogen water or degassed hydrogen water for 4 wk before the operation and received OLV for 60 min and two-lung ventilation for 60 min. Lung tissues were assayed for wet-to-dry ratio, oxidative stress variables, proinflammatory cytokines, and hematoxylin-eosin staining.