General Research
Model: human
Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss
Simplified Version Available
Breathing Easy: How Hydrogen Therapy May Help Fight Chronic Pancreatitis
A 2017 study found that inhaling hydrogen gas helped restore regulatory T cells in mice with chronic pancreatitis, reducing inflammation and improving pancreatic function. This breakthrough could lead to new treatments for the condition. Hydrogen therapy has also shown promise in treating other conditions, such as heart health and lung disease.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Cellular Physiology and Biochemistry Primary Topic Pancreas Secondary TopicPancreatitis Model Mouse Tertiary TopicImmune Dysfunction Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: We found that hydrogen treatment significantly improved multiple symptoms of chronic pancreatitis. The number of Tregs was reduced in chronic pancreatitis mice, while hydrogen treatment restored the Treg loss by L-arginine administrations. Depletion of Tregs abolished the protective effect of hydrogen treatment in chronic pancreatitis. In vitro study showed that hydrogen blocked ROS generation in Tregs and promoted Tregs survival.
Results
Conclusion: Hydrogen treatment showed reliable benefits in controlling the severity of chronic pancreatitis. Our study supported that hydrogen could be used as a novel treatment in chronic pancreatitis patient in the future.