General Research
Model: rat
Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush
Simplified Version Available
New Hope for Eye Injury Treatment: How Hydrogen-Rich Saline Helps Save Vision
A new study finds that hydrogen-rich saline can help save vision in rats with optic nerve crush injuries. The solution reduces inflammation and creates a healthier environment for retinal ganglion cells to survive. This breakthrough offers new hope for treating eye injuries and preventing vision loss in humans.
Read Simplified ArticleAbstract
Publish Year 2014 Country China Rank Positive Journal PLoS One Primary Topic Eye Secondary TopicRetinal Injury Model Rat Tertiary TopicOptic Nerve Crush Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: H&E, gamma synuclein staining and CTB tracing showed that the survival rate of RGCs in hydrogen saline-treated group was significantly higher than that in saline-treated group. Apoptosis of RGCs assessed by TUNEL staining were less observed in hydrogen saline-treated group. The MDA level in retina of H₂ group was much lower than that in placebo group. Furthermore, animals treated with hydrogen saline showed better function of optic nerve in assessments of FVEP and PLR.
Results
Conclusion: These results demonstrated that H₂ protects RGCs and helps preserve the visual function after ONC and had a neuroprotective effect in a rat model subjected to ONC.