General Research
Model: mouse
Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels
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How Hydrogen-Rich Saline Can Protect Your Brain During Surgery
Hydrogen-rich saline may protect the brain during surgery by reducing oxidative stress and mitochondrial dysfunction caused by the anesthetic isoflurane. This could lead to improved patient outcomes and reduced risk of long-term brain damage. More research is needed to confirm the findings, but the results so far are promising.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal American Journal of Translational Research Primary Topic Brain Secondary TopicNeuroprotection Model Cell Culture Tertiary TopicAnesthetic Toxicity (Isoflurane) Vehicle Saline (Dissolved) pH Neutral Application Culture Media Comparison Complement
Methods
Results: We found that HS attenuated isoflurane-induced caspase-3 activation. Moreover, HS treatment mitigated isoflurane-induced ROS accumulation, opening of mitochondrial permeability transition pores, reduction in mitochondrial membrane potential, and reduction in cellular ATP levels. Finally, HS significantly alleviated isoflurane-induced cognitive impairment in mice. Conclusions: Our results suggest that HS attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. These findings warrant further research into the underlying mechanisms of this activity, and indicate that HS has the potential to attenuate anesthesia neurotoxicity.