General Research
Model: rat
Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy
Simplified Version Available
Hope for Shingles Sufferers: How Hydrogen-Rich Saline May Ease Pain
A 2017 study found that hydrogen-rich saline may help ease the pain of post-herpetic neuralgia, a condition that affects millions worldwide. The treatment works by activating autophagy, a process that helps cells recycle damaged parts. This discovery brings hope to those living with this debilitating condition and may lead to new treatments.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Chinese Journal of Cellular and Molecular Immunology Primary Topic Skin Secondary TopicShingles Model Rat Tertiary TopicPost-Herpetic Neuralgia Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Compared with the control group,the rats in the PHN group presented with decreased PWT,increased levels of TNF-α,IL-1β,IL-6,LC3Ⅱ and beclin 1,and down-regulated P62 expression. Compared with PHN group,the rats in the PHN-H2 group and PHN-H2-Rap group showed increased PWT,decreased levels of TNF-α,IL-1β and IL-6,further up-regulated expressions of LC3 and beclin 1 as wel as P62 expression. Compared with PHN-H2 group,the rats in the PHN-H2-3-MA group had reduced PWT,elevated expressions of TNF-α,IL-1β and IL-6,suppressed expressions of LC3 and beclin 1,and enhanced p62 expression.
Results
Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-α,IL-1β,IL-6 in rats with PHN via activating autophagy.