General Research
Model: rat
Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats
Simplified Version Available
How Hydrogen-Rich Saline May Protect the Brain After Cardiac Arrest
A 2017 study found that hydrogen-rich saline reduces stress in the hippocampus, a key area for memory and learning, after cardiac arrest in rats. This could lead to better outcomes for cardiac arrest patients. Hydrogen therapy is also being explored for other health issues, including heart health and lung disease treatment.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Neuroscience Letters Primary Topic Brain Secondary TopicCardiopulmonary Resuscitation (CPR) Model Rat Tertiary TopicHypoxia-Ischemia Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: The rats were randomly divided into three groups, sham group (n=30), ischemia/reperfusion group (n=40) and hydrogen-rich saline group (n=40). The rats in experimental groups were subjected to 4minutes of cardiac arrest and followed by resuscitation. Then they were randomized to receive 5ml/kg of either hydrogen-rich saline or normal saline.
Methods
Results: Hydrogen-rich saline significantly improves survival rate and neurological function. The beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP). Conclusions: Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats.