General Research
Model: rat
Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase–dependent Reactive Oxygen Species
Simplified Version Available
How Hydrogen-Rich Saline Fights Liver Damage in Acute Pancreatitis
A study found that hydrogen-rich saline can reduce liver damage in acute necrotizing pancreatitis by inhibiting inflammation and cell death. This could lead to new treatments for this life-threatening condition. Hydrogen-rich saline works by blocking certain pathways in our cells and reducing toxic chemicals that damage our cells.
Read Simplified ArticleAbstract
Publish Year 2016 Country China Rank Positive Journal Pancreas Primary Topic Liver Secondary TopicLiver Injury Model Rat Tertiary TopicNecrotizing Pancreatitis Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Analyses of serum, lipase, alanine transaminase, and aspartate aminotransferase indicated that ANP-induced AHI model was established successfully and HRS attenuated hepatic dysfunction. Hepatic superoxide dismutase and malondialdehyde levels showed HRS against oxidative stress. Cellular and molecular analyses including p-p38, p-JNK, p-ERK, and caspase-3, caspase-9, NF-κB, and TNF-α in hepatic tissues revealed that HRS attenuated ANP-induced AHI by inhibiting apoptosis and phosphorylation of JNK and p38, as well as NF-κB activation. Conclusions: Hydrogen-rich saline plays a protective role in ANP-induced AHI through inhibiting inflammation and apoptosis, involving JNK and p38 MAPK-dependent reactive oxygen species.