General Research
Model: rat
Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress
Simplified Version Available
New Hope for Neuropathic Pain Relief: How Hydrogen-Rich Saline Can Help
A 2013 study found that hydrogen-rich saline reduced neuropathic pain in rats by decreasing oxidative stress. This breakthrough offers new hope for people suffering from chronic pain. Hydrogen-rich saline could be a safer, more effective alternative to current treatments.
Read Simplified ArticleAbstract
Publish Year 2013 Country China Rank Positive Journal Canadian Journal of Neurological Sciences Primary Topic Brain Secondary TopicNeuropathic Pain Model Rat Tertiary TopicOxidative Stress Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: Thirty SD rats were randomly divided into three groups: sham group was administered sodium chloride by intrathecal injection (n=10); control groups underwent CCI surgery and were administered sodium chloride by intrathecal injection (n=10); vehicle group underwent CCI surgery and was administered hydrogen-rich saline by intrathecal injection (n=10). Drugs were administered in the dose of 100 ul/kg once a day at 0.5 hours before and 1-7 day after CCI surgery. The mechanical thresholds were tested at one day before and 3-14 day after CCI surgery.
Methods
Results: We found that hydrogen-rich saline significantly elevated the mechanical thresholds of neuropathic pain compared to vehicle (physiologic saline) control in CCI rats (p<0.05); it also decreased the levels of myeloperoxidase, maleic dialdehyde, and protein carbonyl in spinal cord by 7 days post-chronic constriction injury(p<0.05). In addition, hydrogen-rich saline also suppressed the expression of p38-mitogen-activated protein kinase (p38MAPK) and brain-derived neurotrophic factor (BDNF) in the spinal cord by 7 days post-chronic constriction injury (p<0.01, p0.05), an ATP receptor.
Results
Conclusion: Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model. Le salin riche en hydrogène atténue la douleur névropathique en réduisant le stress oxydatif.