General Research
Model: rat
Hydrogen-Rich Saline Ameliorates Hepatic Ischemia-Reperfusion Injury Through Regulation of Endoplasmic Reticulum Stress and Apoptosis
Simplified Version Available
How Hydrogen-Rich Saline Can Help Protect Your Liver
A 2017 study found that hydrogen-rich saline can help protect the liver from ischemia-reperfusion injury, a serious condition that can occur during surgery or when blood flow to the liver is cut off. The treatment works by reducing cell stress and preventing cell death, and could lead to new treatments for liver diseases. By exploring natural substances like hydrogen, scientists are making promising discoveries that can improve our health.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Digestive Diseases and Sciences Primary Topic Liver Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Serum ALT and AST levels and tissue MDA content in the I/R + HS groups were significantly lower than those in the I/R + NS groups. Pathological changes were also significantly ameliorated in the HS groups compared with those in the NS groups. Moreover, HS appeared to significantly attenuate hepatic I/R-induced ER stress responses, as indicated by the decreased expression of C/EBP homologous protein, protein-kinase-RNA-like ER kinase, and inositol-requiring protein-1α, as well as the increased expression of GRP78 proteins. Finally, the levels of apoptotic markers such as caspase-3 and TUNEL-positive cells were significantly lower in the HS groups than in the NS control groups, whereas the level of Bcl2 protein increased in the HS groups.
Results
Conclusion: The protective effect of HS can be attributed to ER stress and apoptosis inhibition.