General Research Model: human

Hydrogen Protects Mice From Dermatitis Caused by Local Radiation

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How Hydrogen Gas May Help Prevent Radiation Skin Damage

Hydrogen gas may help prevent radiation skin damage, a common side effect of radiation therapy. A study in mice found that injecting hydrogen gas reduced the severity of radiation-induced dermatitis. This finding could have implications for cancer patients undergoing radiation therapy.

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Abstract

Publish Year 2013 Country China Rank Positive Journal Journal of Dermatological Treatment Primary Topic Skin Secondary TopicCancer Model Rat Tertiary TopicRadioprotection Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous. Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with head-and-neck cancer. Here we analyzed the radioprotective efficacy of hydrogen under conditions of local, single dose or fractionated radiation treatment, and its possible molecular mechanisms. Methods:

Objective

Mice received either single-dose or fractioned irradiation of the head-and-neck area with or without subcutaneous injection of hydrogen solution before irradiation. In vitro, the effect of hydrogen medium on radiation-induced cell viability , apoptosis and biochemical assays was measured. Result: hydrogen significantly reduced the severity of dermatitis, accelerated tissue recovery, and reduced the extent of radiation induced weight loss in mice after a single dose of 15 or 20 Gy but not 25 Gy of radiation. Hydrogen was also protective from cumulative doses of 30 Gy delivered in three fractions, respectively. Hydrogen also protect HaCaT cells from radiation-induced injury, it could significantly inhibit ionizing injury. Conclusion: