General Research
Model: rat
Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model
Simplified Version Available
Healing the Eyes: How Hydrogen Water May Help with Corneal Injuries
A Japanese study found that hydrogen promotes the activation of an enzyme that helps protect cells from damage, which could lead to new treatments for corneal injuries. Hydrogen water may offer a way to support eye health. Further research is needed to explore its potential in human treatments.
Read Simplified ArticleAbstract
Publish Year 2020 Country Japan Rank Positive Journal International Journal of Ophthalmology Primary Topic Eye Secondary TopicCorneal Injury Model Rat Tertiary TopicAlkali Burn Vehicle Saline (Dissolved) pH Neutral Application Irrigation Comparison Complement
Methods
Results: The numbers of both inflammatory and vascular endothelial cells were significantly reduced in the corneas of the H2 group (P<0.01). Furthermore, H2 treatment increased both cytoplasmic SOD1 levels (P<0.01) and activity in corneal epithelial cells (P<0.01). Notably, the SOD1 activity level in the H2 group was approximately 2.5-fold greater than that in the saline group.
Results
Conclusion: H2 treatment suppresses inflammation and neovascularization in the injured cornea and indirectly suppresses oxidative insult to the cornea by upregulating the SOD1 enzyme protein level and activity.