General Research
Model: human
Hydrogen nanobubbles: A novel approach toward radio-sensitization agents
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Bursting with Potential: How Hydrogen Nanobubbles Can Help Fight Cancer
Scientists in Iran discovered that hydrogen nanobubbles can make cancer cells more sensitive to radiation therapy, potentially leading to better cancer treatments with fewer side effects. This breakthrough uses hydrogen gas in a new way, building on existing research into its medical applications. More research is needed, but the results are promising.
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Publish Year 2023 Country Iran Rank Positive Journal Medical Physics Primary Topic Eye Secondary TopicCancer Model Molecular Assay Tertiary TopicNovel Therapy Vehicle Gas pH N/A Application In Vivo Biotic Production Comparison Complement
Background
Purpose: To investigate the efficiency of hydrogen nanobubbles (H2 -NBs) employment during intraocular melanoma brachytherapy using a 106 Ru electron emitter plaque.
Methods
Results: Using a 1% concentration of H2 -NBs, a DEF of 93% and 98% were achieved at the tumor apex of 10 mm from the experimental setup and MC simulation, respectively. For simulated concentrations of 0.1%, 0.3%, 0.5%, 1%, and 4% H2 -NBs, a maximum dose enhancement of 154%, 174%, 188%, 200%, and 300% were achieved, respectively, and a dose reduction was seen at about 3 mm from the plaque surface.
Results
Conclusion: H2 -NBs can be used as an absorbed dose enhancer in 106 Ru eye brachytherapy because of their unique physical characteristics. Reducing plaque implantation time on the patient's eye, reducing sclera absorbed dose, and decreasing the risk of patients' healthy organs irradiation are reported as some of the potential benefits of using H2-NBs. Keywords: Ruthenium-106 ophthalmic plaque; brachytherapy; eye phantom; glass bead dosimeters; hydrogen nanobubbles.
Purpose
Methods: The Monte Carlo (MC) simulation and experimental investigation using a 3D-designed phantom and thermoluminescence dosimetry (TLD) were employed. Various concentrations of H2 -NBs with a diameter of 100 nm were simulated inside tumor tissue. The results were presented as deposited energy and dose enhancement factor (DEF). An equivalent Resin phantom of the human eyeball was made using AutoCAD and 3D-Printer technologies. The glass-bead TLDs dosimeter were employed and placed inside the phantom.