General Research
Model: pig
Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig
Simplified Version Available
How Hydrogen Inhalation Could Save Your Hearing During Cancer Treatment
A study found that hydrogen inhalation can protect against ototoxicity caused by the chemotherapy medication cisplatin. This is exciting news for people undergoing cancer treatment, as hearing loss can have a significant impact on quality of life. Hydrogen inhalation could be a simple and effective way to reduce the risk of ototoxicity and protect hearing.
Read Simplified ArticleAbstract
Publish Year 2017 Country Sweden Rank Positive Journal Frontiers in Cellular Neuroscience Primary Topic Ear Secondary TopicCancer Model Guinea Pig Tertiary TopicChemotherapy Toxicity (Cisplatin) Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Cisplatin induced electrophysiological threshold shifts, hair cell loss, and reduced synaptophysin immunoreactivity in the synapse area around the IHCs and OHCs. H2 inhalation mitigated all these effects. Cisplatin also reduced the OCT2 intensity in the inner and outer pillar cells and in the stria vascularis as well as the CTR1 intensity in the synapse area around the IHCs, the Deiters' cells, and the stria vascularis. H2 prevented the majority of these effects.
Results
Conclusion: H2 inhalation can reduce cisplatin-induced ototoxicity on functional, cellular, and subcellular levels. It is proposed that synaptopathy may serve as a marker for cisplatin ototoxicity. The effect of H2 on the antineoplastic activity of cisplatin needs to be further explored.