General Research
Model: rat
Hydrogen inhalation enhances autophagy via the AMPK/mTOR pathway, thereby attenuating doxorubicin-induced cardiac injur
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Breathe Easy: How Hydrogen Inhalation May Protect Your Heart from Chemotherapy Damage
Hydrogen inhalation may protect the heart from damage caused by chemotherapy by enhancing autophagy via the AMPK/mTOR pathway. A recent study found that hydrogen inhalation attenuated doxorubicin-induced cardiac injury in rats. This simple and non-invasive treatment may have a significant impact on cancer patients undergoing chemotherapy.
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Publish Year 2023 Country China Rank Positive Journal International Immunopharmacology Primary Topic Heart Secondary TopicCancer Model Rat Tertiary TopicChemotherapy Toxicity (Doxorubicin) Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Hydrogen inhalation can improve doxorubicin-induced cardiac function decline and pathological structural abnormalities in rats. It was confirmed by immunofluorescence that hydrogen treatment could restore the expression of autophagy marker protein LC3 (microtubule-associated protein 1 light chain 3) in cardiomyocytes reduced by doxorubicin, while reducing cardiomyocyte apoptosis. Mechanistically, Western blot results consistently showed that hydrogen treatment up-regulated the ratio of p-AMPK (phosphorylated AMP-dependent protein kinase) to AMPK and down-regulated p-mTOR (phosphorylated mammalian target of rapamycin) and mTOR ratio. Conclusions: These results suggest that hydrogen inhalation can activate autophagy through the AMPK/mTOR pathway and protect against myocardial injury induced by doxorubicin. Hydrogen inhalation therapy may be a potential treatment for doxorubicin-induced myocardial injury.