General Research
Model: in_vitro
Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury
Simplified Version Available
How Hydrogen Therapy May Help Heal Traumatic Brain Injuries
Researchers in China have found that hydrogen therapy may help heal traumatic brain injuries by reducing oxidative stress and promoting cell survival. This study used a laboratory model to show that hydrogen improves cell viability and activates a pathway that helps cells grow and function properly. The findings suggest that hydrogen therapy could be a new tool in treating traumatic brain injuries, offering hope for patients and their families.
Read Simplified ArticleAbstract
Publish Year 2020 Country China Rank Positive Journal Neurological Research Primary Topic Brain Secondary TopicTraumatic Brain Injury Model Cell Culture Tertiary TopicOxidative Stress Vehicle Medium (Dissolved) pH Neutral Application Culture Media Comparison Complement
Methods
Results: In the case of TBI, hydrogen was able to improve the decline of cell viability induced by TBI. More importantly, inhibition of PI3 K/Akt/GSK3β signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective effect was regulated by PI3 K/Akt/GSK3β signal pathway and was related to the inhibition of autophagy.
Results
Conclusion: So we concluded that hydrogen improved the cell viability in a microvascular endothelial cell model of TBI partly through inhibition of autophagy, and inhibitory effect of hydrogen on autophagy was exerted by activating PI3 K/Akt/GSK3β signal pathway. These findings enriched our knowledge about the mechanism of hydrogen therapy against TBI.