General Research
Model: rat
Hydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation
Simplified Version Available
How Hydrogen Gas Inhalation Helps Heal Lung Injury After Trauma
A recent study found that inhaling hydrogen gas can help reduce lung injury after a traumatic event like severe bleeding. Hydrogen gas acts as an antioxidant, neutralizing harmful free radicals and promoting healing. This breakthrough could lead to new treatments for people who have experienced severe blood loss.
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Publish Year 2019 Country South Korea Rank Positive Journal Journal of Thoracic Disease Primary Topic Lung Secondary TopicShock Model Rat Tertiary TopicHemorrhagic Shock Vehicle Gas pH N/A Application Inhalation Comparison Complement
Background
Methods: Rats weighing 300-500 g were divided into three groups: sham, HSR, and hydrogen (H2)/HSR groups. In the latter two groups, HSR was induced via femoral vein cannulation. Gas containing 2% hydrogen gas was inhaled only by those in the H2/HSR group. Lung tissue and abdominal aorta blood were obtained for histologic examination and arterial blood gas analyses, respectively. Neutrophil infiltration and proinflammatory mediators were also measured.
Methods
Results: PO2 was lower in the HSR and H2/HSR groups than in the sham group. Blood lactate level was not significantly different between the sham and H2/HSR groups, but it was significantly higher in the HSR group. Infiltration of inflammatory cells into the lung tissues was more frequent in the HSR group. Myeloperoxidase (MPO) activity was significantly different among the three groups (highest in the HSR group). All proinflammatory mediators, except IL-6, showed a significant difference among the three groups (highest in the HSR group). Conclusions: Inhalation of 2% hydrogen gas after HSR minimized the extent of lung injury by decreasing MPO activity and reducing infiltration of inflammatory cells into lung tissue.