General Research
Model: rat
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension
Simplified Version Available
How Hydrogen Gas Can Help Reduce High Blood Pressure
A Japanese study found that hydrogen gas can help reduce left ventricular hypertrophy in rats with high blood pressure. The study suggests that hydrogen gas may have antioxidant properties that can help reduce damage to cells in the body. While the study was done on rats, it's exciting to think about what it could mean for humans with high blood pressure.
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Publish Year 2018 Country Japan Rank Positive Journal Clinical and Experimental Hypertension Primary Topic Heart Secondary TopicHigh Blood Pressure Model Rat Tertiary TopicCardiac Hypertrophy Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: IVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were significantly lower in the 8% NaCl + H2 group than the 8% NaCl group. There was no significant difference in systolic blood pressure between the two groups.
Results
Conclusion: Our findings suggest that chronic H2 gas inhalation may help prevent LV hypertrophy in hypertensive DS rats.
Purpose
Methods: Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with H2 gas (8% NaCl + H2 group), and control rats maintained on a diet containing 0.3% NaCl until 12 weeks of age (0.3% NaCl group). H2 gas was supplied through a gas flowmeter and delivered by room air (2% hydrogenated room air, flow rate of 10 L/min) into a cage surrounded by an acrylic chamber. We evaluated interventricular septal wall thickness (IVST), LV posterior wall thickness (LVPWT), and LV mass using echocardiography.