General Research
Model: rat
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and anti-oxidant effects
Simplified Version Available
How Hydrogen Can Help Ease High Blood Pressure in the Lungs
A 2015 study found that hydrogen can help ease pulmonary hypertension in rats by reducing inflammation and oxidative stress. This natural element may offer a new treatment option for humans with this serious condition. As research continues, hydrogen therapy may also help with other health issues.
Read Simplified ArticleAbstract
Publish Year 2015 Country Japan Rank Positive Journal Journal of Thoracic and Cardiovascular Surgery Primary Topic Heart Secondary TopicHigh Blood Pressure Model Rat Tertiary TopicOxidative Stress Vehicle Water (Electrolysis) pH Alkaline Application Ingestion Comparison Complement
Methods
Results: Pulmonary arterial hypertension was significantly exacerbated in group M compared to group C, but was significantly improved in group H. Vascular density was significantly reduced in group M, but not in group H. Adventitial macrophages, antiproliferating cell nuclear antigen - and 8-OHdG-positive cells, and stromal cell-derived factor-1 and monocyte chemoattractant protein-1 expressions were significantly increased in group M, but improved in group H. Expressions of phosphorylated STAT3 and NFAT were up-regulated in group M, but improved in group H. Conclusions: Molecular hydrogen ameliorates MCT-induced PAH in rats by suppressing macrophage accumulation, reducing oxidative stress and modulating the STAT3/NFAT axis.