General Research
Model: mouse
Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy
Simplified Version Available
How Hydrogen Helps Fight Sepsis and Protects Lung Health
Researchers found that hydrogen can help reduce cell damage and acute lung injury in sepsis by triggering a process that gets rid of damaged cell parts. This discovery opens up new possibilities for treating sepsis and other conditions that affect lung health. Hydrogen therapy may become a valuable tool in protecting our health, from sepsis to heart health and liver protection.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Inflammation Research Primary Topic Lung Secondary TopicSepsis Model Cell Culture Tertiary TopicMultiple Organ Dysfunction Syndrome Vehicle Medium (Dissolved) pH Neutral Application Culture Media Comparison Complement
Background
Results: Hydrogen ameliorated cell injury and enhanced mitophagy in macrophages stimulated by LPS. PINK1 was required for the mitigation of the cell impairment in LPS-stimulated macrophages by hydrogen treatment. PINK1 knockdown abrogated the beneficial effects of hydrogen on mitophagy in LPS-stimulated macrophages. Hydrogen inhibited acute lung injury in CLP mice via activation of PINK1-mediated mitophagy.
Results
Conclusion: These results suggest that PINK1-mediated mitophagy plays a key role in the protective effects of hydrogen against cell injury in LPS-induced inflammation and CLP-induced acute lung injury.