General Research
Model: mouse
Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the Nrf2 pathway in sepsis-associated encephalopathy
Simplified Version Available
How Hydrogen Helps Reduce Brain Damage from Sepsis
A recent study found that hydrogen can help reduce brain damage from sepsis by calming down the immune system's aggressive response and reducing inflammation. This is exciting news for anyone interested in new treatments for brain damage. Hydrogen therapy is a promising area of research that could lead to better outcomes for people with sepsis-associated encephalopathy.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Neuroscience Primary Topic Brain Secondary TopicSepsis Model Cell Culture Tertiary TopicEncephalopathy Vehicle Medium (Dissolved) pH Neutral Application Culture Media Comparison Complement
Methods
Results: H2 attenuated microglial polarization from the M1 to the M2 phenotype, cytokine release and TLR/NF-κb activation and protected neurons from LPS-activated microglia-induced injury via the Nrf2 pathway. SAE activated Nrf2 expression, and H2 further improved Nrf2 expression in SAE mice. H2 alleviated microglial polarization from the M1 to the M2 phenotype and cytokine release in the cerebral cortex and improved neuronal injury or cognitive dysfunction in SAE mice and wild-type mice but not in Nrf2-/- mice.
Results
Conclusion: H2 exerts antineuroinflammatory effects associated with TLR4/NF-κB signaling activation and neuroprotective effects by inhibiting the excessive release of proinflammatory cytokines, neuronal loss and apoptosis in vitro and in vivo through the Nrf2 pathway.