General Research
Model: mouse
High concentration of hydrogen gas alleviates Lipopolysaccharide-induced lung injury via activating Nrf2 signaling pathway in mice
Simplified Version Available
Breathe Easy: How Hydrogen Gas May Help Heal Lung Injuries
A recent study found that high concentrations of hydrogen gas can alleviate lipopolysaccharide-induced lung injuries in mice by activating the Nrf2 signaling pathway. This discovery may lead to new treatments for lung injuries and conditions like sepsis. Hydrogen gas has anti-inflammatory and antioxidant properties, making it a promising therapeutic agent.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal International Immunopharmacology Primary Topic Lung Secondary TopicSepsis Model Mouse Tertiary TopicLung Injury Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: HCH Inhalation significantly alleviated LPS-induced pathological alterations of lung, and reduced the protein concentration, the wet/dry weight ratio, and the MPO activity of lung tissue. HCH Inhalation improved LPS-induced increasement in caspase-3 activity and the number of TUNEL-positive cells. HCH inhalation attenuated the LPS induced increased total cell content and polymorphonuclear granulocyte content, and pro-inflammatory cytokines, Nrf2 and NF-κB expression. HCH could not produce protective effct in Nrf2-knockout mice.
Results
Conclusion: HCH can effectively alleviate LPS-induced ALI, which may be related to activation of Nrf2 signaling pathway and inhibition of inflammatory response and cell apoptosis mediated by NF-κB.