General Research
Model: mouse
High Concentration Hydrogen Mitigates Sepsis-Induced Acute Lung Injury in Mice by Alleviating Mitochondrial Fission and Dysfunction
Simplified Version Available
Hydrogen Therapy: A Breath of Fresh Air for Lung Injury
A recent study found that high-concentration hydrogen therapy may help alleviate sepsis-induced acute lung injury in mice by reducing mitochondrial fission and dysfunction. This non-invasive treatment has shown promise in improving lung function and reducing the risk of multiple organ failure. While more research is needed, the results are promising for human health and warrant further exploration.
Read Simplified ArticleAbstract
Publish Year 2023 Country China Rank Positive Journal Journal of Personalized Medicine Primary Topic Lung Secondary TopicSepsis Model Mouse Tertiary TopicMultiple Organ Failure (MOF) Vehicle Gas pH N/A Application Inhalation Comparison Complement
Background
Methods: The moderate and severe septic models were prepared by cecal ligation and puncture. Hydrogen with different concentrations was inhaled for one hour at 1 h and 6 h after the corresponding surgery. The arterial blood gas of mice during hydrogen inhalation was monitored in real time, and the 7-day survival rate of mice with sepsis was recorded. The pathological changes of lung tissues and functions of livers and kidneys were measured. The changes of oxidation products, antioxidant enzymes and pro-inflammatory cytokines in lungs and serums were detected. Mitochondrial function was measured.
Methods
Results: The inhalation of 2% or 67% hydrogen improves the 7-day survival rate and reduces acute lung injury as well as liver and kidney injury in sepsis. The therapeutic effect of 67% hydrogen inhalation on sepsis was related to increasing antioxidant enzyme activity, reducing oxidation products and pro-inflammatory cytokines in lungs and serums. Compared with the Sham group, mitochondrial dysfunction was alleviated in hydrogen groups. Conclusions: Hydrogen inhalation by high or low concentration can both significantly improve sepsis; however, a high concentration demonstrates a better protective effect. High concentration hydrogen inhalation can significantly improve the mitochondrial dynamic balance and reduce the lung injury in septic mice.