General Research
Model: human
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
Simplified Version Available
Can Hydrogen-Rich Water Improve Cognitive Function?
A 2018 study published in Current Alzheimer Research found that drinking hydrogen-rich water improved cognitive function in both animal models and human participants with mild cognitive impairment. The study suggests that hydrogen-rich water reduces oxidative stress in the brain, protecting brain cells and improving cognitive function. The findings are promising, especially for people with mild cognitive impairment, and could be a valuable addition to a healthy lifestyle.
Read Simplified ArticleAbstract
Publish Year 2018 Country Japan Rank Positive Journal Current Alzheimer Research Primary Topic Brain Secondary TopicDementia Model Human Tertiary TopicCognitive Impairment Vehicle Water, Commercial (Blue Mercury) pH Neutral Application Ingestion Comparison Complement
Background
Methods: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a randomized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year.
Methods
Results: In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was longer than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).
Results
Conclusion: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.