General Research
Model: human
Effects of Hydrogen in Prevention of Corneal Endothelial Damage During Phacoemulsification: A Prospective Randomized Clinical Trial
Simplified Version Available
How Hydrogen Helps Protect Your Eyes During Cataract Surgery
A study found that using hydrogen-rich saline during cataract surgery reduced corneal endothelial damage. This is important for protecting your eyes and ensuring the best possible outcome. Hydrogen is being explored for its potential to help with various health issues, making it an exciting area of medical research.
Read Simplified ArticleAbstract
Publish Year 2019 Country Japan Rank Positive Journal American Journal of Ophthalmology Primary Topic Eye Secondary TopicSurgery/Transplantation Model Human Tertiary TopicSurgical Injury Vehicle Saline (Dissolved) pH Neutral Application Irrigation Comparison Complement
Methods
Results: Reduction rates of ECD (mean ± standard deviation) were 16.0%±15.7% at 1 day, 15.4%±16.1% at 1 week, and 18.4%±14.9% at 3 weeks in the control group, compared to 6.5%±8.7% at 1 day (P = .003), 9.3%±11.0% at 1 week (P = .039), and 8.5%±10.5% at 3 weeks (P = .004) in the H2 groups. These rates were significantly smaller in the H2 group at all time points. Conclusions: H2 dissolved in irrigation solution reduced corneal endothelial damage during phacoemulsification. This suggests that a considerable part of the corneal endothelial damage during phacoemulsification is caused by oxidative stress, and that H2 is useful in clinical phacoemulsification.
Purpose
Methods: Thirty-two patients who had cataracts of similar nucleus hardness in both eyes (age: 75.4±7.68 years; 17 males, 15 females) were recruited. Phacoemulsification was performed using a solution of dissolved H2 in one eye, and a conventional solution in the contralateral eye. Endothelial cell density (ECD) at the center of the cornea was measured using noncontact specular microscopy preoperatively and at 1 day, 1 week, and 3 weeks postoperatively.