General Research
Model: pig
Comparative study on protective effect of hydrogen rich saline and adipose-derived stem cells on hepatic ischemia-reperfusion and hepatectomy injury in swine
Simplified Version Available
New Hope for Liver Surgery: How Hydrogen Rich Saline and Stem Cells Can Help
Researchers explored the protective effects of hydrogen rich saline and adipose-derived stem cells on liver damage during surgery. The study found that both treatments reduced liver damage and improved liver function, offering new hope for safer and more effective liver surgery. With more research, these findings could lead to better outcomes for patients undergoing liver surgery.
Read Simplified ArticleAbstract
Publish Year 2019 Country China Rank Positive Journal Biomedicine and Pharmacotherapy Primary Topic Liver Secondary TopicSurgery/Transplantation Model Pig Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Stem Cells
Methods
Results: Compared with the IRI group, both ADSCs and HRS groups can promote liver function recovery, reduce oxidative stress, reduce inflammation, and promote liver regeneration. Compared with HRS, ALT and TBIL in ADSCs group were significantly decreased at 3 d, and AST was significantly reduced at 1 d. The activities of SOD and GSH-Px in ADSCs group were significantly higher than that in HRS group, but the MDA level in HRS group was markedly lower than that in ADSCs group at 1 d. IL-1β was significantly lower in the ADSCs group than in the HRS group at 1 day after operation. The expressions of HGF and PCNA were significantly higher than that in the HRS group at 3 day after surgery.
Results
Conclusion: Our study has demonstrated that HRS and ADSCs have significant hepatoprotective effects in miniature pigs after HIRI and hepatectomy injury. However, liver parenchyma injection of ADSCs is more beneficial to the recovery of liver function than portal vein injection of HRS.