General Research
Model: mouse
Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice
Simplified Version Available
How Hydrogen-Rich Water Helps Fight Fatty Liver Disease
A study found that hydrogen-rich water can help alleviate fatty liver disease in mice by reducing oxidative stress and inflammation. This could be a new way to help treat the disease in humans. Drinking hydrogen-rich water could be a simple way to help protect your liver.
Read Simplified ArticleAbstract
Publish Year 2017 Country Taiwan Rank Positive Journal World Journal of Gastroenterology Primary Topic Liver Secondary TopicFatty Liver Disease (Alcoholic) Model Mouse Tertiary TopicAlcohol Toxicity Vehicle Water (Mg-Chemico) pH Alkaline Application Gavage Comparison Complement
Methods
Results: The in vitro study showed that HRW directly scavenged hydrogen peroxide. The in vivo study showed that HRW increased expression of acyl ghrelin, which was correlated with food intake. HRW treatment significantly reduced EtOH-induced increases in serum alanine aminotransferase, aspartate aminotransferase, triglycerol and total cholesterol levels, hepatic lipid accumulation and inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6. HRW attenuated malondialdehyde level, restored glutathione depletion and increased superoxide dismutase, glutathione peroxidase and catalase activities in the liver. Moreover, HRW reduced TNF-α and IL-6 levels but increased IL-10 and IL-22 levels.
Results
Conclusion: HRW protects against chronic EtOH-induced liver injury, possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and IL-22, thus activating antioxidant enzymes against oxidative stress.