General Research
Model: human
A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics
Simplified Version Available
Can Hydrogen Water Help with Parkinson's Disease? New Study Offers Hope
Researchers are exploring the potential benefits of hydrogen water for managing Parkinson's disease symptoms. A 2016 study looked into whether drinking hydrogen water, in addition to taking the standard medication levodopa, could help. This area of research offers hope for new, complementary therapies. Hydrogen water, with its antioxidant properties, may help reduce oxidative stress, potentially alleviating symptoms or slowing the disease's progression.
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Publish Year 2016 Country Japan Rank Neutral Journal BMC Neuroscience Primary Topic Brain Secondary TopicParkinson's Disease Model Human Tertiary TopicOxidative Stress Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement Levodopa
Background
Methods: Changes in the total UPDRS scores from baseline to the 8(th), 24(th), 48(th), and 72(nd) weeks, and after the 8(th) week, will be evaluated. The primary endpoint of the efficacy of this treatment in PD is the change in the total UPDRS score from baseline to the 72(nd) week. The changes in UPDRS part II, UPDRS part III, each UPDRS score, PD Questionnaire-39 (PDQ-39), and the modified Hoehn and Yahr stage at these same time-points, as well as the duration until the protocol is finished because additional levodopa is required or until the disease progresses, will also be analyzed. Adverse events and screening laboratory studies will also be examined. Participants in the hydrogen water group will drink 1000 mL/day of H2 water, and those in the placebo water group will drink normal water. One-hundred-and-seventy-eight participants with PD (88 women, 90 men; mean age: 64.2 [SD 9.2] years, total UPDRS: 23.7 [11.8], with levodopa medication: 154 participants, without levodopa medication: 24 participants; daily levodopa dose: 344.1 [202.8] mg, total levodopa equivalent dose: 592.0 [317.6] mg) were enrolled in 14 hospitals and were randomized. Discussion: This study will confirm whether H2 water can improve PD symptoms.